La-Bio Research

TOXICITY STUDIES

The OECD Guidelines for the Testing of Chemicals is a collection of about 150 of the most relevant internationally agreed testing methods used by government, industry and independent laboratories to identify and characterise potential hazards of chemicals.

La-Bio Research offers a wide range of Toxicity Studies including:

Our Services Toxicity Studies

Acute Oral Toxicity

OECD Testing Guideline 423

Based on a stepwise procedure with the use of a minimum number of animals per step, sufficient information is obtained on the acute toxicity of the test substance to enable its classification.

The substance is administered orally to a group of experimental animals at one of the defined doses. The substance is tested using a stepwise procedure, each step using three animals of a single sex (normally females).

Acute Dermal Toxicity

OECD Testing Guideline 402

This method provides information on health hazard likely to arise from short-term exposure to a test chemical by dermal route.

Test chemicals should not be administered at doses that are known to cause marked pain and distress due to potential corrosive or severely irritant actions.

The method provides information on the hazardous properties and allows the substance to be classified for acute toxicity according to the Globally Harmonised System of classification and labelling of chemicals.

Acute Dermal Irritation-Corrosion

OECD Testing Guideline 404

This method provides information on health hazard likely to arise from exposure to liquid or solid test substance by dermal application.

This Test Guideline recommends sequential testing strategies, which include the performance of validated and accepted in vitro or ex vivo tests for corrosion/irritation.

Acute Eye Irritation

OECD Testing Guideline 405

This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye.

Skin Sensitization

OECD Testing Guideline 406

This method provides information on health hazard likely to arise from exposure to test substance via intradermal injection and/or applied epidermically.

In this Test Guideline, the methods preferred over others: the Guinea Pig Maximisation Test (GPMT) of Magnusson and Kligman which uses adjuvant and the Buehler Test which uses non-adjuvant.

Acute Inhalation Toxicity

OECD Testing Guideline 403

This test provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation.

Our Services Subacute & Subchronic Toxicity

Repeated Dose 28 Day Toxicity
Studies in Rodents

OECD Testing Guideline 407

This method provides information on health hazard likely to arise from exposure to test substance via oral administration.

The method is based on the repeated oral administration of the substance of interest during one limited period (one dose level daily for 28 days).

Repeated Dose 90 Day Toxicity
in Rodents

OECD Testing Guideline 408

This method provides information on health hazard likely to arise from exposure to test substance via oral administration.

The determination of sub-chronic oral toxicity using repeated doses may be carried out after initial information on toxicity has been obtained from acute or repeated dose 28-day toxicity tests.

The method is based on the repeated oral administration of the substance of interest over a prolonged period (one dose level daily for 90 days).

Subacute Inhalation Toxicity:
28-Day Study

OECD Testing Guideline 412

This revised Test Guideline 412 (TG 412) has been designed to fully characterize test article toxicity by the inhalation route following repeated exposure for a limited period of time (28 days), and to provide data for quantitative inhalation risk assessments.

It was updated in 2017 to enable the testing and characterisation of effects of nanomaterials tested.

Subchronic Inhalation Toxicity:
90-Day Study

OECD Testing Guideline 413

This revised Test Guideline 413 (TG 413) has been designed to fully characterize test article toxicity by the inhalation route following repeated exposure for a period of 90 days, and to provide data for quantitative inhalation risk assessments.